Skin or Pill
Transdermal administration delivers medication through the skin via patches, and although comparable to oral-dosage forms in efficacy, how do the two very different methods of medicating a patient compare?
The most obvious difference to a patient is the extra few extra seconds required to open and apply a patch vs simply swallowing a tablet, however, this too is amongst its greatest benefit as transdermal administration avoids the first-pass effect of metabolism associated with the oral route and therefore allows for improved bioavailability.
The only real issue for the pharma world with transdermals is that they require medication to be hydrophobic; something which industry experts Greene Street Pharmaceuticals see as a “challenge rather than inhibitor” according to CEO, Frank Jones.
And given that transdermal patches allow the prolonged release of medications which can improve patient adherence, and also minimize adverse effects due to lower drug peak concentrations compared to oral dosages, Frank sees a huge opportunity and indeed, currently has over a dozen products in his development portfolio.
With such clear benefits, it's easy to see why patches are an increasingly interesting option for many patients.
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May 17, 2021